Cytokeratin expression in reactive cylindrical ciliated epithelium of the sinonasal tract in chronic inflammation

Introduction. Currently, there are limited papers on changes in the pseudostratified ciliated columnar epithelium of sinonasal tract chronic inflammatory processes, particularly basal cell hyperplasia. The latter is similar to dysplasia varying severity stratified squamous nonkeratinized epithelium. Studying can clarify histogenesis various epithelial tumors tract, including papillomas. research aimed at studying cytokeratin profile reactive cylindrical a nonspecific process. Materials and methods. We analyzed surgical materials obtained from 567 patients diagnosed with rhinosinusitis nasal polyps. performed an immunohistochemical study 20 cases using panel antibodies Ki-67, Stathmin, Cytokeratin 7, 10/13, 14, 17, 18, 19. Results. Using hematoxylin eosin staining, we detected hyperplasia different 74% (419 cases). In 13% (73 cases), was combined foci metaplasia. Based results, identified 4 types morphological layer specific profile: mild hyperplasia, moderate severe areas Conclusion. Simultaneous expression cytokeratins cells, for both simple compound epithelia, allows us consider this area have highest potential development Keywords: papilloma,